Chiral Synthesis

We offer custom synthesis of chiral molecules through separation of racemic material as well as modern asymmetric synthesis.

  • Asymmetric induction
  • Chiral pool
  • Organocatalysis
  • Enzymatic reactions (reductions, esterases, decarboxylases)
  • Single and double stereo-differentiating reactions
  • Desymmetrization

Fermentation

We have developed significant expertise in fermentation to produce APIs, Intermediates and biocatalysts.

  • Expert inhouse biotechnology team
  • Close collaboration of biotechnology department with chemistry department
  • Approx. 300m2 commercial fermentation workshop, from 50L to 23,000L fermenters

Synthetic Biology

Our protein expression platform has established four recombinant expression systems from prokaryotic (E.coli, Bacillus) and eukaryotic (Yeast, Brassica napus(plant cell system)).Capabilities:

  • 2,400 m2 biocatalysis labs that can handle 5-10 projects simultaneously
  • a large in-house library including 2000+ enzymes from commercially available sources enabling rapid screening

Our integrated synthetic biology platform offers a one-stop solution:

  • Contract research of protein/peptide expression
  • Peptide development and manufacturing
  • API industrial strain development
  • Biocatalysis development, replacing chemical process with enzyme technology

Photochemistry

  • Photochemistry provides with green, high efficiency, low pollution benefits;
  • We are manufacturing APIs in ton scale by using photochemistry technology.

Polymorph and Salt

  • Discovery of new polymorph, crystallization process development and optimization.
  • Milling and micronization:equipped with different milling device, can meet with different PSD requests.

Oligonucleotide development

  • Aurisco has an integrated Oligonucleotides process development and manufacturing platform from preclinical to commercial. We support the development and manufacturing of a variety of oligonucleotide modalities including DNA, RNA, Morpholino oligonucleotide (PMO), etc.

Analytical services

  • IPC and release methods development and validation for small and large molecules
  • API and Drug Product release testing ICH stability studies
  • Reference standard characterization and qualification
  • Potential Genotoxic Impurities (PGI) method development, validation and testing
  • Impurity/degradant isolation and structure elucidation
  • Oligonucleotide and Peptide analysis
  • Physical property characterization
  • Microbial testing

Key analytical technologies

  • Chromatography: UPLC, HPLC, IC, GC
  • Mass spectrometry: LC-MS, LC/MS/MS,GC-MS, UPLC-UV-MS, UHPLC-QToF
  • Solid state characterization: XRPD, DSC, TGA , PSD
  • Identification: NMR
  • General testing: KF, UV-Vis,
  • PSD testing: Malvern 2000,3000, Sympack
  • Elemental analyzer: ICP-MS
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